Rxfp2^tm1Aia
Targeted Allele Detail

Summary

• Symbol: Rxfp2^tm1Aia
• Name: relaxin/insulin-like family peptide receptor 2; targeted mutation 1, Alexander I Agoulnik
• MGI ID: MGI:2388129
• Synonyms: Great^ko
• Gene: Rxfp2 Location: Chr5:149942140-150005649 bp, + strand Genetic Position: Chr5, 89.23 cM
• Alliance: Rxfp2^tm1Aia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79124
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Duplication, Insertion
• Rxfp2^tm1Aia involves 1 genes/genome features (Rxfp2) View all
• Mutation details: Gene targeting resulted in the duplication of exons 12-16 and the insertion of vector sequence into the 16 intron of the endogenous gene. (J:79124)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxfp2 Mutation: 53 strains or lines available

References

• Original: J:79124 Gorlov IP, et al., Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet. 2002 Sep 15;11(19):2309-18
• All: 12 reference(s)