Rasgrf1^tm1Pds
Targeted Allele Detail

Summary

• Symbol: Rasgrf1^tm1Pds
• Name: RAS protein-specific guanine nucleotide-releasing factor 1; targeted mutation 1, Paul D Soloway
• MGI ID: MGI:2388130
• Gene: Rasgrf1 Location: Chr9:89791961-89909030 bp, + strand Genetic Position: Chr9, 47.31 cM
• Alliance: Rasgrf1^tm1Pds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75397
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequence consisting of the 40 41-mer repeats that follow the differentially methylated domain. The selection cassette was removed by in vivo cre mediated recombination. (J:75397, J:185711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgrf1 Mutation: 66 strains or lines available

References

• Original: J:75397 Yoon BJ, et al., Regulation of DNA methylation of Rasgrf1. Nat Genet. 2002 Jan;30(1):92-6
• All: 3 reference(s)