Ikzf3^tm1Kge
Targeted Allele Detail

Summary

• Symbol: Ikzf3^tm1Kge
• Name: IKAROS family zinc finger 3; targeted mutation 1, Katia Georgopoulos
• MGI ID: MGI:2388132
• Synonyms: Aio-, Aiodelta7-, Aiolos-
• Gene: Ikzf3 Location: Chr11:98355728-98436857 bp, - strand Genetic Position: Chr11, 61.75 cM
• Alliance: Ikzf3^tm1Kge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50626
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.35 kb region of exon 7 including the 5' splice acceptor site was replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in homozygous mutant animals as demonstrated by Northern blot analysis of spleen, bone marrow, and thymus samples using probes to exons 1-6 and exon 7. Immunohistochemical analysis of spleen sections from 4 week old homozygous mutant mice did not detect protein product. (J:50626)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf3 Mutation: 30 strains or lines available

References

• Original: J:50626 Wang JH, et al., Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998 Oct;9(4):543-53
• All: 12 reference(s)