Gpr132^tm1Witt
Targeted Allele Detail

Summary

• Symbol: Gpr132^tm1Witt
• Name: G protein-coupled receptor 132; targeted mutation 1, Owen N Witte
• MGI ID: MGI:2388138
• Synonyms: G2A^-
• Gene: Gpr132 Location: Chr12:112814493-112831848 bp, - strand Genetic Position: Chr12, 61.25 cM, cytoband F2
• Alliance: Gpr132^tm1Witt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 (98% of the total coding sequence) with an IRES-lacZ-PGK-neo cassette. Absence of gene expression was confirmed by RT-PCR analysis of pre-B and -T cells from homozygous mutant animals. (J:69473)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr132 Mutation: 25 strains or lines available

References

• Original: J:69473 Le LQ, et al., Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 2001 May;14(5):561-71
• All: 17 reference(s)