Cacna1b^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Cacna1b^tm1Hssh
• Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2388140
• Synonyms: Cav2.2^-
• Gene: Cacna1b Location: Chr2:24493899-24653164 bp, - strand Genetic Position: Chr2, 16.58 cM, cytoband A2
• Alliance: Cacna1b^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71480
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding a portion of the IS3 region was replaced with a cassette containing GFP and neo. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:71480)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1b Mutation: 104 strains or lines available

References

• Original: J:71480 Kim C, et al., Altered Nociceptive Response in Mice Deficient in the alpha(1B) Subunit of the Voltage-Dependent Calcium Channel. Mol Cell Neurosci. 2001 Aug;18(2):235-45
• All: 6 reference(s)