Plcg1^tm2Gcrp
Targeted Allele Detail

Summary

• Symbol: Plcg1^tm2Gcrp
• Name: phospholipase C, gamma 1; targeted mutation 2, Graham Carpenter
• MGI ID: MGI:2388142
• Synonyms: Plcg1-
• Gene: Plcg1 Location: Chr2:160573230-160617680 bp, + strand Genetic Position: Chr2, 80.97 cM
• Alliance: Plcg1^tm2Gcrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39281
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Sequence encoding the X domain and both SH3 domains were deleted by the insertion of a cassette containing both lacZ and neo. Only truncated protein was detected by Western blot analysis of MEFs derived from homozygous mutant mice. TV-II targeting vector. (J:39281)

Expression

In Mice Carrying this Mutation:

29 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg1 Mutation: 48 strains or lines available

References

• Original: J:39281 Ji QS, et al., Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development [see comments]. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2999-3003
• All: 3 reference(s)