Mat1a^tm1Jmm
Targeted Allele Detail

Summary

• Symbol: Mat1a^tm1Jmm
• Name: methionine adenosyltransferase 1A; targeted mutation 1, Jose M Mato
• MGI ID: MGI:2388143
• Gene: Mat1a Location: Chr14:40826992-40846369 bp, + strand Genetic Position: Chr14, 22.36 cM, cytoband C1
• Alliance: Mat1a^tm1Jmm page

Liver histology from 8 month old Mat1a^tm1Jmm/Mat1a^tm1Jmm mice fed a normal diet

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69408
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 3 via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Northern and Western blot of liver RNA and proteins. (J:69408)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mat1a Mutation: 18 strains or lines available

Notes

Expression of Mat2a mRNA was induced 3-fold in homozygous mutant animals. Expression of Afp mRNA was also increased in homozygous mutants.

References

• Original: J:69408 Lu SC, et al., Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5560-5
• All: 8 reference(s)