Ddr2^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Ddr2^tm1Kln
• Name: discoidin domain receptor family, member 2; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:2388155
• Synonyms: DDR2-
• Gene: Ddr2 Location: Chr1:169799876-169938331 bp, - strand Genetic Position: Chr1, 76.84 cM, cytoband H1-H5
• Alliance: Ddr2^tm1Kln page

Skull comparison of Ddr1^tm1Wfv/Ddr1^tm1Wfv, Ddr2^tm1Kln/Ddr2^tm1Kln and Ddr2^tm1Kln/Ddr2⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74580
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the ATP binding region of the kinase domain was replaced by a neo cassette inserted by homologous recombination. The absence of normal trancsript and normal protein was confirmed by Northern and Western blot analyses. In vitro studies showed normal proliferation of fibroblasts derived from homozygous mutant mice after infection with a retrovirus containing the wild-type cDNA. (J:74580)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddr2 Mutation: 61 strains or lines available

References

• Original: J:74580 Labrador JP, et al., The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May;2(5):446-52
• All: 3 reference(s)