Dstn^corn1-2J
Spontaneous Allele Detail

Summary

• Symbol: Dstn^corn1-2J
• Name: destrin; corneal disease 1, 2 Jackson
• MGI ID: MGI:2388156
• Gene: Dstn Location: Chr2:143757251-143785244 bp, + strand Genetic Position: Chr2, 70.89 cM, cytoband H1
• Alliance: Dstn^corn1-2J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The corn1-2J mouse was identified as an allele of corn1 by complementation analysis. The mutation was identifed as a C-to-T transition at coding nucleotide position 316 in exon 3. This mutation results in a Pro106Ser amino acid change that is predicted to affect the binding of the protein to F- and G-actin. (J:83125)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dstn Mutation: 43 strains or lines available

References

• Original: J:83125 Ikeda S, et al., Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet. 2003 May 1;12(9):1029-37
• All: 6 reference(s)