Top3a^tm1Jcw
Targeted Allele Detail

Summary

• Symbol: Top3a^tm1Jcw
• Name: topoisomerase (DNA) III alpha; targeted mutation 1, James C Wang
• MGI ID: MGI:2388159
• Synonyms: deltatop3alpha
• Gene: Top3a Location: Chr11:60630884-60668191 bp, - strand Genetic Position: Chr11, 37.81 cM
• Alliance: Top3a^tm1Jcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45652
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the active site tyrosine was replaced with a PGK-neo cassette via homologous recombination. (J:45652)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top3a Mutation: 61 strains or lines available

References

• Original: J:45652 Li W, et al., Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1010-3
• All: 1 reference(s)