Vax2^tm1Grl
Targeted Allele Detail

Summary

• Symbol: Vax2^tm1Grl
• Name: ventral anterior homeobox 2; targeted mutation 1, Greg Lemke
• MGI ID: MGI:2388160
• Synonyms: Vax2^-
• Gene: Vax2 Location: Chr6:83688246-83715295 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Vax2^tm1Grl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74240
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neo cassette inserted by homologous recombination. RT-PCR analysis identified shortened transcript in homozygous mutant mice, lacking the targeted region, which encoded the first two alpha helices (residues 83 through 145) of the homeodomain. A loss of immunoreactivity was observed in the homozygous mutant retina. (J:74240)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vax2 Mutation: 16 strains or lines available

References

• Original: J:74240 Mui SH, et al., The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002 Feb;129(3):797-804
• All: 4 reference(s)