Gfi1b^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Gfi1b^tm1Sho
• Name: growth factor independent 1B; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:2388162
• Synonyms: Gfi-1b^-, Gfi-1b^-/-(neoR+)
• Gene: Gfi1b Location: Chr2:28499462-28511994 bp, - strand Genetic Position: Chr2, 19.38 cM
• Alliance: Gfi1b^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74523
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region included the translational start codon. (J:74523)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1b Mutation: 21 strains or lines available

References

• Original: J:74523 Saleque S, et al., The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev. 2002 Feb 1;16(3):301-6
• All: 1 reference(s)