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Ascl1tm1(Neurog2)Fgu
Targeted Allele Detail
Summary
Symbol: Ascl1tm1(Neurog2)Fgu
Name: achaete-scute family bHLH transcription factor 1; targeted mutation 1, Francois Guillemot
MGI ID: MGI:2388165
Synonyms: Ascl1Ngn2KI, Mash1KINgn2
Gene: Ascl1  Location: Chr10:87326681-87329522 bp, - strand  Genetic Position: Chr10, 43.64 cM
Alliance: Ascl1tm1(Neurog2)Fgu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74525
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Ascl1tm1(Neurog2)Fgu expresses 1 gene
 
Mutation detailsThe entire coding region of the endogenous gene was replaced with that of Neurog2. The 5' and 3' untranslated regions of the endogenous gene were left intact, allowing Neurog2 to be expressed in the Ascl1 domain. A single loxP site was left in an intron following the inserted Neurog2 coding region. (J:74525)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129S1/Sv * 129X1/SvJ
 
involves: 129S1/Sv * 129X1/SvJ
 
Phenotypes:
Affected Systems
show or hide all annotated terms
   
cellular
abnormal neuron apoptosis
mortality/aging
neonatal lethality, complete penetrance
nervous system
abnormal neuron apoptosis
abnormal locus ceruleus morphology
abnormal dorsal interneuron 2 morphology
abnormal dorsal interneuron 3 morphology
abnormal dorsal interneuron LA morphology
abnormal ventral interneuron 2 morphology
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ascl1 Mutation:  28 strains or lines available
References
Original:  J:74525 Parras CM, et al., Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 2002 Feb 1;16(3):324-38
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory

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