Ascl1^{tm1(Neurog2)Fgu}
Targeted Allele Detail

Summary

• Symbol: Ascl1^{tm1(Neurog2)Fgu}
• Name: achaete-scute family bHLH transcription factor 1; targeted mutation 1, Francois Guillemot
• MGI ID: MGI:2388165
• Synonyms: Ascl1^Ngn2KI, Mash1^KINgn2
• Gene: Ascl1 Location: Chr10:87326681-87329522 bp, - strand Genetic Position: Chr10, 43.64 cM
• Alliance: Ascl1^{tm1(Neurog2)Fgu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74525
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ascl1^{tm1(Neurog2)Fgu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Neurog2

• Mutation details: The entire coding region of the endogenous gene was replaced with that of Neurog2. The 5' and 3' untranslated regions of the endogenous gene were left intact, allowing Neurog2 to be expressed in the Ascl1 domain. A single loxP site was left in an intron following the inserted Neurog2 coding region. (J:74525)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ascl1 Mutation: 28 strains or lines available

References

• Original: J:74525 Parras CM, et al., Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 2002 Feb 1;16(3):324-38
• All: 13 reference(s)