Gjd2^tm1Mony
Targeted Allele Detail

Summary

• Symbol: Gjd2^tm1Mony
• Name: gap junction protein, delta 2; targeted mutation 1, Hannah Monyer
• MGI ID: MGI:2388290
• Synonyms: Cx36^-, Cx36KO
• Gene: Gjd2 Location: Chr2:113840082-113844100 bp, - strand Genetic Position: Chr2, 57.54 cM, cytoband F3
• Alliance: Gjd2^tm1Mony page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71116
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 2 was deleted and replaced with a neomycin resistance cassette via homologous recombination. Exon 2 encodes all but 71 nucleotides of the open reading frame. Absence of gene expression was confirmed by in situ hybridization analysis of brain sections from postnatal day 15 homozygous mutant animals. (J:71116)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjd2 Mutation: 23 strains or lines available

References

• Original: J:71116 Hormuzdi SG, et al., Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice. Neuron. 2001 Aug 16;31(3):487-95
• All: 16 reference(s)