Ntf3^tm1Mpin
Targeted Allele Detail

Summary

• Symbol: Ntf3^tm1Mpin
• Name: neurotrophin 3; targeted mutation 1, Max-Planck-Institute of Neurobiology
• MGI ID: MGI:2388319
• Synonyms: NT-3 -
• Gene: Ntf3 Location: Chr6:126078375-126143703 bp, - strand Genetic Position: Chr6, 60.45 cM
• Alliance: Ntf3^tm1Mpin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79302
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette via homologous recombination. Northern blot analysis showed transcript levels to be reduced by approximately 50% in heterozygous mutant mice. (J:79302)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntf3 Mutation: 24 strains or lines available

References

• Original: J:79302 Airaksinen MS, et al., Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron. 1996 Feb;16(2):287-95
• All: 6 reference(s)