Hmox1^tm1Poss
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1Poss
• Name: heme oxygenase 1; targeted mutation 1, Kenneth D Poss
• MGI ID: MGI:2388322
• Synonyms: Hmox1^-, HO-1^-, HO1^-
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1Poss page

Iron-loading of Hmox1^tm1Poss/Hmox1^tm1Poss tissues.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79254
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.7 kb fragment encompassing exons 3, 4, and a portion of 5 was replaced with a neomycin selection cassette. The deleted region consisted of approximately 85% of the coding region (226 residues). A low level of aberrantly spliced transcript was identified in homozygous mutant mice by Northern blot analysis of total splenic RNA. (J:79254)

Disease models

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 35 strains or lines available

References

• Original: J:79254 Poss KD, et al., Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10919-24
• All: 62 reference(s)