Hmox2^tm1Poss
Targeted Allele Detail

Summary

• Symbol: Hmox2^tm1Poss
• Name: heme oxygenase 2; targeted mutation 1, Kenneth D Poss
• MGI ID: MGI:2388325
• Synonyms: HO-2^-, HO2^-, HO-2^delta
• Gene: Hmox2 Location: Chr16:4544225-4584606 bp, + strand Genetic Position: Chr16, 2.46 cM, cytoband B1
• Alliance: Hmox2^tm1Poss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29523
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Approximately 80% of the coding region was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included the putative membrane spanning region. Transcript was undetected in homozygous mutant mice by Northern blot analysis of brain tissue. An assay based on bilirubin production indicated complete functional ablation in homozygous mutant mice. (J:29523)

Expression

In Mice Carrying this Mutation:	21 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmox2 Mutation: 27 strains or lines available

References

• Original: J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
• All: 53 reference(s)