Adora1^tm1Jgsc
Targeted Allele Detail

Summary

• Symbol: Adora1^tm1Jgsc
• Name: adenosine A1 receptor; targeted mutation 1, Jurgen Schnermann
• MGI ID: MGI:2388340
• Synonyms: A1^-, A1AR^-, A1KO
• Gene: Adora1 Location: Chr1:134126963-134163169 bp, - strand Genetic Position: Chr1, 58.15 cM, cytoband E4
• Alliance: Adora1^tm1Jgsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71091
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence of the gene was deleted and replaced with a lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of kidney mRNA. (J:71091)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adora1 Mutation: 23 strains or lines available

References

• Original: J:71091 Sun D, et al., Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9983-8
• All: 58 reference(s)