Slc9a3^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Slc9a3^tm1Ges
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3; targeted mutation 1, Gary E Shull
• MGI ID: MGI:2388341
• Synonyms: Nhe3^-, NHE-3 -, Slc9a3^-
• Gene: Slc9a3 Location: Chr13:74269576-74317561 bp, + strand Genetic Position: Chr13, 40.15 cM
• Alliance: Slc9a3^tm1Ges page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70885
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 6. Northern blot analysis of kidney and intestinal RNA detected a truncated mutant transcript lacking codons 320-821. The residues endcoded by the deleted sequences are required for Na+/H+ exhange. (J:70885)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Slc9a3^tm1Ges

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc9a3 Mutation: 45 strains or lines available

References

• Original: J:70885 Schultheis PJ, et al., Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet. 1998 Jul;19(3):282-5
• All: 54 reference(s)