Epor^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Epor^tm1Jni
• Name: erythropoietin receptor; targeted mutation 1, James N Ihle
• MGI ID: MGI:2388345
• Synonyms: Epor-H, EporH, H
• Gene: Epor Location: Chr9:21870193-21874802 bp, - strand Genetic Position: Chr9, 7.93 cM
• Alliance: Epor^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70036
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was truncated by replacement of exon 8 sequences encoding the distal half of the cytoplasmic domain with a neomycin resistance cassette. Expression of the mutant allele was confirmed by RT-PCR analysis of bone marrow RNA from homozygous mutant animals. (J:70036)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epor Mutation: 26 strains or lines available

References

• Original: J:70036 Zang H, et al., The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J. 2001 Jun 15;20(12):3156-66
• All: 11 reference(s)