Eportm2Jni
Targeted Allele Detail
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Symbol: |
Eportm2Jni |
Name: |
erythropoietin receptor; targeted mutation 2, James N Ihle |
MGI ID: |
MGI:2388346 |
Synonyms: |
Epor-HM, EporHM, HM |
Gene: |
Epor Location: Chr9:21870193-21874802 bp, - strand Genetic Position: Chr9, 7.93 cM
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Alliance: |
Eportm2Jni page
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Germline Transmission: |
Earliest citation of germline transmission:
J:70036
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was truncated by replacement of exon 8 sequences encoding the distal half of the cytoplasmic domain with a neomycin resistance cassette. A tyrosine to phenylalanine substitution at residue 343 (Y343F) was also introduced. Expression of the mutant allele was confirmed by RT-PCR analysis of bone marrow RNA from homozygous mutant animals. Sequence analysis of RT-PCR products verified the presence of the Y343F amino acid substitution.
(J:70036)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Epor Mutation: |
27 strains or lines available
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Original: |
J:70036 Zang H, et al., The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J. 2001 Jun 15;20(12):3156-66 |
All: |
11 reference(s) |
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