Prdm2^tm1Shg
Targeted Allele Detail

Summary

• Symbol: Prdm2^tm1Shg
• Name: PR domain containing 2, with ZNF domain; targeted mutation 1, Shi Huang
• MGI ID: MGI:2388354
• Synonyms: RIZ1^-
• Gene: Prdm2 Location: Chr4:142833961-142939560 bp, - strand Genetic Position: Chr4, 76.84 cM
• Alliance: Prdm2^tm1Shg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71406
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The RIZ1 protein product was disrupted by insertion of a neomycin resistance cassette into the center of the sequence encoding the PR domain in exon 5. The RIZ2 protein product, which begins transcription at exon 6, was not affected by the gene targeting event. Absence of RIZ1 gene expression in homozygous mutant animals was verified by Northern blot of adult mouse brain RNA, Western blot of adult testis proteins, and RT-PCR analysis. (J:71406)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prdm2^tm1Shg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm2 Mutation: 99 strains or lines available

References

• Original: J:71406 Steele-Perkins G, et al., Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev. 2001 Sep 1;15(17):2250-62
• All: 4 reference(s)