Sdc3^tm1Rau
Targeted Allele Detail

Summary

• Symbol: Sdc3^tm1Rau
• Name: syndecan 3; targeted mutation 1, Heikki Rauvala
• MGI ID: MGI:2388360
• Synonyms: NS ko, SDC-3^-
• Gene: Sdc3 Location: Chr4:130519855-130553629 bp, + strand Genetic Position: Chr4, 63.63 cM
• Alliance: Sdc3^tm1Rau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70502
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing the majority of exon 3 and and all of exon 4 was replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of postnatal brain RNA. Immunostaining of hippocampal neurons derived from homozygous mutant mice and grown in vitro indicated an absence of protein. (J:70502)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sdc3 Mutation: 22 strains or lines available

References

• Original: J:70502 Reizes O, et al., Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Cell. 2001 Jul 13;106(1):105-16
• All: 16 reference(s)