Sag^tm1Jnc
Targeted Allele Detail

Summary

• Symbol: Sag^tm1Jnc
• Name: S-antigen, retina and pineal gland (arrestin); targeted mutation 1, Jeannie Chen
• MGI ID: MGI:2388373
• Synonyms: arr1-, Arrb1^tm1Jnc, arrestin^-
• Gene: Sag Location: Chr1:87731402-87772880 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Sag^tm1Jnc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43294
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the 5' promoter and exons 1 and 2 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was undetectable in rod cells of homozygous mutant animals as shown by Western blot analysis. (J:43294)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Sag Mutation: 44 strains or lines available

References

• Original: J:43294 Xu J, et al., Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature. 1997 Oct 2;389(6650):505-9
• All: 44 reference(s)