Pax3^{tm1(FOXO1A)Gcg}
Targeted Allele Detail

Summary

• Symbol: Pax3^{tm1(FOXO1A)Gcg}
• Name: paired box 3; targeted mutation 1, Gerard C Grosveld
• MGI ID: MGI:2388378
• Synonyms: Pax3-FKHR
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^{tm1(FOXO1A)Gcg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79365
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Pax3^{tm1(FOXO1A)Gcg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FOXO1 (2308)

  Foxo1

  (MGI:1890077)

  The 3' half of FOXO1 is fused to mouse Pax3

• Mutation details: To replicate t(2;13), a chromosomal transloction associated with the pediatric disease alveolar rhabdomyosarcoma, a sequence fragment from a PAX3-FOXO1A fusion cDNA was inserted at the endogenous locus via homologous recombination. The last 50 bp of the endogenous exon 7 were replaced with related PAX3 sequence and a 3' portion of FOXO1A. Various analyses indicated low levels of expression of the knock-in allele. (J:79365)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 50 strains or lines available

References

• Original: J:79365 Lagutina I, et al., Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol Cell Biol. 2002 Oct;22(20):7204-16
• All: 1 reference(s)