Gjd2^tm1Paul
Targeted Allele Detail

Summary

• Symbol: Gjd2^tm1Paul
• Name: gap junction protein, delta 2; targeted mutation 1, David L Paul
• MGI ID: MGI:2388383
• Synonyms: Cx36-
• Gene: Gjd2 Location: Chr2:113840082-113844100 bp, - strand Genetic Position: Chr2, 57.54 cM, cytoband F3
• Alliance: Gjd2^tm1Paul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71117
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a lacZ-IRES-ALPP-neo construct via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by immunostaining of frozen retina sections. (J:71117)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjd2 Mutation: 23 strains or lines available

References

• Original: J:71117 Deans MR, et al., Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36. Neuron. 2001 Aug 16;31(3):477-85
• All: 62 reference(s)