Klk8tm1Lth
Targeted Allele Detail
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Symbol: |
Klk8tm1Lth |
Name: |
kallikrein related-peptidase 8; targeted mutation 1, Richard Lathe |
MGI ID: |
MGI:2388384 |
Gene: |
Klk8 Location: Chr7:43447001-43453250 bp, + strand Genetic Position: Chr7, 28.26 cM, cytoband B4
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Alliance: |
Klk8tm1Lth page
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Germline Transmission: |
Earliest citation of germline transmission:
J:71533
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacment of the region of exon 3 encoding the aspartic acid region of the catalytic site with a lacZ-neo cassette. The targeting construct introduces stop codons in all 3 reading frames. Northern blot analysis of brain RNA verified the absence of gene expression in homozygous mutant animals. X-gal staining of mutant brains did not detect any lacZ expression.
(J:71533)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Klk8 Mutation: |
22 strains or lines available
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Original: |
J:71533 Davies B, et al., Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. J Neurosci. 2001 Sep 15;21(18):6993-7000 |
All: |
1 reference(s) |
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