Drd2^tm1Schm
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1Schm
• Name: dopamine receptor D2; targeted mutation 1, Claudia Schmauss
• MGI ID: MGI:2388386
• Synonyms: D2 -, D2R-KO
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1Schm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79483
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the amino terminal extracellular domain, transmembrane spanning domains 1 and 2, and the first intracellular domain. Transcript was undetected by Northern blot analysis of RNA obtained from the dorsal striatum of homozygous mutant mice. (J:79483)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:79483 Jung MY, et al., Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience. 1999;91(3):911-24
• All: 13 reference(s)