Drd3^tm1Schm
Targeted Allele Detail

Summary

• Symbol: Drd3^tm1Schm
• Name: dopamine receptor D3; targeted mutation 1, Claudia Schmauss
• MGI ID: MGI:2388387
• Synonyms: D3 -
• Gene: Drd3 Location: Chr16:43574389-43643295 bp, + strand Genetic Position: Chr16, 28.44 cM
• Alliance: Drd3^tm1Schm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79483
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. While normal transcript was undetected by RT-PCR analysis, a truncated transcript encoding the first 3 transmembrane spanning domains was detected. (J:79483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd3 Mutation: 59 strains or lines available

References

• Original: J:79483 Jung MY, et al., Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience. 1999;91(3):911-24
• All: 7 reference(s)