Cnga3^tm1Biel
Targeted Allele Detail

Summary

• Symbol: Cnga3^tm1Biel
• Name: cyclic nucleotide gated channel alpha 3; targeted mutation 1, Martin Biel
• MGI ID: MGI:2388388
• Synonyms: CNG3^-
• Gene: Cnga3 Location: Chr1:37257317-37302465 bp, + strand Genetic Position: Chr1, 15.46 cM, cytoband B
• Alliance: Cnga3^tm1Biel page

Retinal morphology of 2 month old Cnga3^tm1Biel/Cnga3^tm1Biel and wild-type mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56020
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 7 with a neomycin resistance cassette. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of retina RNA. (J:56020)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnga3 Mutation: 27 strains or lines available

References

• Original: J:56020 Biel M, et al., Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7
• All: 53 reference(s)