Gjd2^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjd2^tm1Kwi
• Name: gap junction protein, delta 2; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:2388389
• Synonyms: Cx36 -
• Gene: Gjd2 Location: Chr2:113840082-113844100 bp, - strand Genetic Position: Chr2, 57.54 cM, cytoband F3
• Alliance: Gjd2^tm1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70839
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 2 and 170 bp of flanking noncoding sequences were replaced with a floxed HPRT minigene in the opposite orientation. RT-PCR analysis did not detect gene expression in the retina or brain of homozygous mutant animals. (J:70839, J:95216)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjd2 Mutation: 23 strains or lines available

References

• Original: J:70839 Guldenagel M, et al., Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36. J Neurosci. 2001 Aug 15;21(16):6036-44
• All: 22 reference(s)