Tnfsf10^tm1Sdg
Targeted Allele Detail

Summary

• Symbol: Tnfsf10^tm1Sdg
• Name: tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Lisa M Sedger
• MGI ID: MGI:2388390
• Synonyms: TRAIL^-, TRAIL-Apo2L^-
• Gene: Tnfsf10 Location: Chr3:27371226-27393814 bp, + strand Genetic Position: Chr3, 10.82 cM, cytoband A3
• Alliance: Tnfsf10^tm1Sdg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 and all of exon 3 were replaced by a neomycin selection cassette inserted by homologous recombination. Splicing of untargeted exons results in a frameshift mutation. Truncated transcript was detected by RT-PCR analysis of RNA obtained from homozygous mutant splenocytes. A premature stop codon was identified by sequence analyis of this transcript. (J:79085)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf10 Mutation: 24 strains or lines available

References

• Original: J:79085 Sedger LM, et al., Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Eur J Immunol. 2002 Aug;32(8):2246-54
• All: 28 reference(s)