Krt6a/Krt6b^tm1Der
Targeted Allele Detail

Summary

• Symbol: Krt6a/Krt6b^tm1Der
• Name: keratin 6A; targeted mutation 1, Dennis R Roop
• MGI ID: MGI:2388395
• Synonyms: K6ab-null, MK6a/b^-
• Gene: Krt6a Location: Chr15:101598363-101602746 bp, - strand Genetic Position: Chr15, 56.97 cM
• Alliance: Krt6a/Krt6b^tm1Der page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70812
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: An 18 kb region containing the entire coding sequences of Krt2-6a and Krt-6b, and including 10.5 kb of intervening sequences, was deleted and replaced with an HPRT-neo minigene via homologous recombination. Absence of expression of both genes in homozygous mutant animals was confirmed by RNase protection assay of skin and hair follicles. (J:70812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt6a Mutation: 25 strains or lines available

References

• Original: J:70812 Wojcik SM, et al., Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b. J Cell Biol. 2001 Aug 6;154(3):619-30
• All: 3 reference(s)