Gas1^tm1Fan
Targeted Allele Detail

Summary

• Symbol: Gas1^tm1Fan
• Name: growth arrest specific 1; targeted mutation 1, Chen-Ming Fan
• MGI ID: MGI:2388397
• Synonyms: Gas1^-
• Gene: Gas1 Location: Chr13:60322219-60325179 bp, - strand Genetic Position: Chr13, 31.92 cM, cytoband B3-C2
• Alliance: Gas1^tm1Fan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70735
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was verified by Western blot analysis of protein extracts from E15 homozygous mutant embryos. (J:70735)

Expression

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	46 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gas1 Mutation: 14 strains or lines available

References

• Original: J:70735 Lee CS, et al., Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol. 2001 Aug 1;236(1):17-29
• All: 9 reference(s)