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Tpgs1Gt(ROSA22)Sor
Gene trapped Allele Detail
Summary
Symbol: Tpgs1Gt(ROSA22)Sor
Name: tubulin polyglutamylase complex subunit 1; gene trap ROSA22, Philippe Soriano
MGI ID: MGI:2388468
Synonyms: Gm16517Gt(ROSA)22Sor Gm16517Gt(ROSA)22Sor Gm16517Gt(ROSA)22Sor, Gtrgeo22Gt(ROSABetageo)22Sor, ROSA22
Gene: Tpgs1  Location: Chr10:79505273-79511961 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Tpgs1Gt(ROSA22)Sor page
Mutation
origin
Mutant Cell Line:  FHCRC-GT-ROSA22
Germline Transmission:  Earliest citation of germline transmission: J:79292
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: ROSABetageo
 
Mutation detailsA ROSA Beta-geo gene trap vector randomly integrated into an intron between the two coding exons of the endogenous locus. Wild-type mRNA was undetected by RT-PCR analysis of total RNA obtained from homozygous mutant testes tissue. Transcript levels produced by adjacent genes, Madcam1 and Cdc34, were normal, indicating that they were unaffected by the insertion. The expression pattern of the integrated beta-galactosidase sequence was determined to be similar to that of the endogenous gene as determined by in situ hybridization. (J:79292)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpgs1 Mutation:  87 strains or lines available
References
Original:  J:79292 Campbell PK, et al., Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Genetics. 2002 Sep;162(1):307-20
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory