Slc22a8^tm1Ngm
Targeted Allele Detail

Summary

• Symbol: Slc22a8^tm1Ngm
• Name: solute carrier family 22 (organic anion transporter), member 8; targeted mutation 1, Sanjay K Nigam
• MGI ID: MGI:2388472
• Synonyms: Oat3^-
• Gene: Slc22a8 Location: Chr19:8568618-8589199 bp, + strand Genetic Position: Chr19, 5.44 cM
• Alliance: Slc22a8^tm1Ngm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78014
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region putatively encoded transmembrane domain 2. Normal transcript was undetected by Northern blot analysis of RNA obtained from homozygous mutant kidney tissue. (J:78014)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc22a8 Mutation: 32 strains or lines available

References

• Original: J:78014 Sweet DH, et al., Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43
• All: 15 reference(s)