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Il6sttm1Ern
Targeted Allele Detail
Summary
Symbol: Il6sttm1Ern
Name: interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst
MGI ID: MGI:2388478
Synonyms: gp130757F, gp130F, gp130Y757F, gp130Y757F
Gene: Il6st  Location: Chr13:112600604-112643394 bp, + strand  Genetic Position: Chr13, 63.73 cM
Alliance: Il6sttm1Ern page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79073
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe Ptpn11 binding domain, encoded by sequence in exon 17, was disrupted by homologous recombination of a construct containing missense mutations at codons 757 (tyrosine to phenylalanine) and 760 (valine to alanine). Furthermore, an IRES-neo cassette was inserted into the 3' region of exon 17. A biochemical assay of liver tissue showed that the Il6st mediated signalling pathway was disrupted in mutant mice. (J:79073)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Il6sttm1Ern
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 13 strains available      Cell Lines: 0 lines available
Carrying any Il6st Mutation:  80 strains or lines available
References
Original:  J:79073 Tebbutt NC, et al., Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002 Oct;8(10):1089-97
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory