Hoxd3^tm2Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxd3^tm2Mrc
• Name: homeobox D3; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:2388512
• Synonyms: Hoxd3-, Hoxd3^null
• Gene: Hoxd3 Location: Chr2:74542337-74578615 bp, + strand Genetic Position: Chr2, 44.13 cM, cytoband C2
• Alliance: Hoxd3^tm2Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60296
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a self-excising neomycin resistance cassette into exon 2. Following removal of the neo cassette, 249 bp of endogenous exon 2 sequences were replaced with a single loxP site. (J:60296)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd3 Mutation: 13 strains or lines available

References

• Original: J:60296 Greer JM, et al., Maintenance of functional equivalence during paralogous Hox gene evolution [see comments]. Nature. 2000 Feb 10;403(6770):661-5
• All: 2 reference(s)