Hoxd3^{tm3(Hoxa3)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxd3^{tm3(Hoxa3)Mrc}
• Name: homeobox D3; targeted mutation 3, Mario R Capecchi
• MGI ID: MGI:2388516
• Synonyms: Hoxd3^A3
• Gene: Hoxd3 Location: Chr2:74542337-74578615 bp, + strand Genetic Position: Chr2, 44.13 cM, cytoband C2
• Alliance: Hoxd3^{tm3(Hoxa3)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60296
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The entire coding region of Hoxd3 was replaced with the coding region of the Hoxa3 gene. The 5' and 3' flanking sequences and the intron are those of the Hoxd3 locus.The 3' end of the Hox3a replacement gene was fused to an 11 amino acid c-myc epitope, followed by a self-excising neomycin resistance cassette. Upon removal of the neo cassette a single loxP site is left behind. (J:60296)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd3 Mutation: 13 strains or lines available

References

• Original: J:60296 Greer JM, et al., Maintenance of functional equivalence during paralogous Hox gene evolution [see comments]. Nature. 2000 Feb 10;403(6770):661-5
• All: 1 reference(s)