Hoxa3^{tm2(Hoxd3)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxa3^{tm2(Hoxd3)Mrc}
• Name: homeobox A3; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:2388565
• Synonyms: Hoxa3-, Hoxa3^D3
• Gene: Hoxa3 Location: Chr6:52146042-52190316 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa3^{tm2(Hoxd3)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60296
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The entire coding region of Hoxa3 was replaced with the coding region of the Hoxd3 gene. The 5' and 3' flanking sequences and the intron are those of the Hoxa3 locus. The 3' end of the Hox3d replacement gene was fused to an 11 amino acid c-myc epitope, followed by a self-excising neomycin resistance cassette. Upon removal of the neo cassette a single loxP site is left behind. (J:60296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa3 Mutation: 24 strains or lines available

References

• Original: J:60296 Greer JM, et al., Maintenance of functional equivalence during paralogous Hox gene evolution [see comments]. Nature. 2000 Feb 10;403(6770):661-5
• All: 1 reference(s)