Mutation details: This transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Phenotypes
View phenotypes and curated references for all genotypes (concatenated display).
J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
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