Tg(MtTGFA)42Lmb
Transgene Detail

Summary

• Symbol: Tg(MtTGFA)42Lmb
• Name: transgene insertion 42, Glenn Merlino
• MGI ID: MGI:2388567
• Synonyms: line MT42, MT42, MT-TGF-alpha, MT/TGF-alpha line MT42, TGF-alpha, Tg(Mt1-TGFA)42Lmb
• Transgene: Tg(MtTGFA)42Lmb Location: unknown
• Alliance: Tg(MtTGFA)42Lmb page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MtTGFA)42Lmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFA (7039)

  Tgfa	(MGI:98724)

• Mutation details: This transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Tg(MtTGFA)100Lmb). (J:28452)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MtTGFA)42Lmb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
• All: 40 reference(s)