About   Help   FAQ
Tg(MtTGFA)42Lmb
Transgene Detail
Summary
Symbol: Tg(MtTGFA)42Lmb
Name: transgene insertion 42, Glenn Merlino
MGI ID: MGI:2388567
Synonyms: line MT42, MT42, MT-TGF-alpha, MT/TGF-alpha line MT42, TGF-alpha, Tg(Mt1-TGFA)42Lmb
Transgene: Tg(MtTGFA)42Lmb  Location: unknown  
Alliance: Tg(MtTGFA)42Lmb page
Transgene
origin
Strain of Origin:  CD-1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MtTGFA)42Lmb expresses 1 gene
 
Mutation detailsThis transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Tg(MtTGFA)100Lmb). (J:28452)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(MtTGFA)42Lmb
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory