Tg(CD4-HIV)1Pjo
Transgene Detail

Summary

• Symbol: Tg(CD4-HIV)1Pjo
• Name: transgene insertion 1, Paul Jolicoeur
• MGI ID: MGI:2388569
• Synonyms: CD4C/HIV^WT
• Transgene: Tg(CD4-HIV)1Pjo Location: unknown
• Alliance: Tg(CD4-HIV)1Pjo page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Mouse CD4 enhancer sequences, the human CD4 promoter, 8.8 kb of HIV sequences, and an SV40 polyadenylation signal was used for the transgene. The enhancer and promoter sequences were used to drive expression in CD4+ T cells and cells of the dendritic/macrophage lineage. Northern blot analysis showed high transgene expression in the thymus, moderate expression in spleen and lymph nodes, and weak expression in kidneys, lungs, intestines, and liver. (J:78757)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four transgenic founder lines were established and exhibit similar disease phenotypes and time course of disease development.

References

• Original: J:78757 Hanna Z, et al., Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease. J Virol. 1998 Jan;72(1):121-32
• All: 5 reference(s)