Del(6Dlx6-Dlx5)1Tlu
Targeted Allele Detail

Summary

• Symbol: Del(6Dlx6-Dlx5)1Tlu
• Name: deletion, Chr 6, Thomas Lufkin 1; targeted mutation 1, Thomas Lufkin
• MGI ID: MGI:2388594
• Synonyms: Dlx5/6^-, Dlx5/6^lacZ, Dlx5/Dlx6^tm1Tlu, Dlx6/Dlx5^tm1Tlu, Dlx6^lacZ
• Gene: Del(6Dlx6-Dlx5)1Tlu Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76480
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(6Dlx6-Dlx5)1Tlu involves 3 genes/genome features (Dlx6os1, Dlx6, Dlx5) View all
• Mutation details: An 11 kb genomic region spanning the homeoboxes of Dlx6 and Dlx5 was deleted and replaced with a lacZ-neo cassette using a single homologous recombination event. Absence of gene expression was confirmed by whole mount in situ hybridization of day E10.5 homozygous mutant embryos. (J:76480)

Disease models

Expression

In Structures Affected by this Mutation:

30 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(6Dlx6-Dlx5)1Tlu Mutation: 0 strains or lines available

References

• Original: J:76480 Robledo RF, et al., The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 1;16(9):1089-101
• All: 10 reference(s)