Gdi1^tm1Toni
Targeted Allele Detail

Summary

• Symbol: Gdi1^tm1Toni
• Name: GDP dissociation inhibitor 1; targeted mutation 1, Daniela Toniolo
• MGI ID: MGI:2388605
• Gene: Gdi1 Location: ChrX:73348618-73355473 bp, + strand Genetic Position: ChrX, 37.97 cM, cytoband B-C1
• Alliance: Gdi1^tm1Toni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79454
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding regions of exons 1 through 4 were replaced by a cassette containing lacZ followed by a floxed neo. Protein was undetected by Western blot analysis of brain tissue obtained from male hemizygous mice. (J:79454)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdi1 Mutation: 15 strains or lines available

References

• Original: J:79454 D'Adamo P, et al., Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Hum Mol Genet. 2002 Oct 1;11(21):2567-80
• All: 3 reference(s)