Rr282726^tm1Dhr
Targeted Allele Detail

Summary

• Symbol: Rr282726^tm1Dhr
• Name: regulatory region 282726; targeted mutation 1, David H Raulet
• MGI ID: MGI:2388606
• Synonyms: H^-, HsA^-, Trgc1^tm1Dhr
• Gene: Rr282726 Location: Chr13:19366601-19366800 bp, . strand Genetic Position: Chr13, Syntenic
• Alliance: Rr282726^tm1Dhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75624
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The cis-acting HsA enhancer element was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was excised by transient expression of cre recombinase in correctly targeted ES cells. (J:75624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr282726 Mutation: 0 strains or lines available

References

• Original: J:75624 Xiong N, et al., Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development. Immunity. 2002 Mar;16(3):453-63
• All: 1 reference(s)