Esr1^tm1.1Lja
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.1Lja
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, J Larry Jameson
• MGI ID: MGI:2388616
• Synonyms: ERalpha^AA, ERalpha^NERKI, NERKI, NERKI^-
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.1Lja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79228
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The floxed neo cassette was removed from Esr^tm1Lja by in vivo cre mediated recombination. The glutamate to alanine and glycine to alanine missense mutations at codons 207 and 208 were left intact. Expression of mutant transcript and protein was verified by RT-PCR and Western blot analyses of liver tissue. (J:79228)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Esr1^tm1.1Lja

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:79228 Jakacka M, et al., An Estrogen Receptor (ER)alpha Deoxyribonucleic Acid-Binding Domain Knock-In Mutation Provides Evidence for Nonclassical ER Pathway Signaling in Vivo. Mol Endocrinol. 2002 Oct;16(10):2188-201
• All: 27 reference(s)