Syt1^tm5Sud
Targeted Allele Detail

Summary

• Symbol: Syt1^tm5Sud
• Name: synaptotagmin I; targeted mutation 5, Thomas C Sudhof
• MGI ID: MGI:2388629
• Synonyms: D232N
• Gene: Syt1 Location: Chr10:108333511-108846843 bp, - strand Genetic Position: Chr10, 56.52 cM
• Alliance: Syt1^tm5Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutation: Disruption caused by insertion of vector
• Mutation details: An aspartate to asparagine missense mutation (D232N) was introduced into the C2A domain via homologous recombination. Western blot of brain homogenates from homozygous mutant animals verified the presence of protein expression. (J:79208)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syt1 Mutation: 41 strains or lines available

References

• Original: J:79208 Fernandez-Chacon R, et al., Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. J Neurosci. 2002 Oct 1;22(19):8438-46
• All: 1 reference(s)