Lat^tm1.1Lov
Targeted Allele Detail

Summary

• Symbol: Lat^tm1.1Lov
• Name: linker for activation of T cells; targeted mutation 1.1, Paul E Love
• MGI ID: MGI:2388631
• Synonyms: LATY136F^m
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm1.1Lov page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77099
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Animals carrying the mutation Lat^tm1Lov were crossed to a cre-expressing line to excise the floxed neomycin cassette, leaving behind the tyrosine to phenylalanine substitution at position 136 (Y136F), and resulting in the mutant line Lat^tm1.1Lov. Residue 136 is critical for Plcg1 binding. Presence of the mutant allele and the integrity of the gene were confirmed by sequence analysis. (J:77099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 10 strains or lines available

References

• Original: J:77099 Sommers CL, et al., A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 2002 Jun 14;296(5575):2040-3
• All: 9 reference(s)