Fzd3^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd3^tm1Nat
• Name: frizzled class receptor 3; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:2388632
• Synonyms: fz3(-)
• Gene: Fzd3 Location: Chr14:65429898-65499912 bp, - strand Genetic Position: Chr14, 34.09 cM
• Alliance: Fzd3^tm1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79213
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding regions of the exons 1 and 2 were replaced with a cassette containing lacZ and neo genes. The deleted region encoded the amino terminal signal sequence and a conserved extracellular domain that has been previously been shown to be involved wiht Wnt binding. The expression pattern of beta-galactosidase replicated that of the endogenous gene. (J:79213)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd3 Mutation: 32 strains or lines available

References

• Original: J:79213 Wang Y, et al., Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci. 2002 Oct 1;22(19):8563-73
• All: 21 reference(s)