Foxg1^tm1(tTA)Lai
Targeted Allele Detail

Summary

• Symbol: Foxg1^tm1(tTA)Lai
• Name: forkhead box G1; targeted mutation 1, Eseng Lai
• MGI ID: MGI:2388671
• Synonyms: BF1(-^tTA), Foxg1^tTA
• Gene: Foxg1 Location: Chr12:49429666-49433650 bp, + strand Genetic Position: Chr12, 21.78 cM
• Alliance: Foxg1^tm1(tTA)Lai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78115
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region was replaced with a tetracycline transactivator (tTA) gene and neomycin cassette. The tTA sequence was fused in-frame following the first 13 codons of the gene. In situ hybridization analysis of E13.5 mutant embryos demonstrates that tTA expression closely matches that of Foxg1 in the telencephalon and olfactory epithelium. (J:78115)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxg1 Mutation: 29 strains or lines available

References

• Original: J:78115 Hanashima C, et al., Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanisms. J Neurosci. 2002 Aug 1;22(15):6526-36
• All: 21 reference(s)